Hepatitis C Medicines

Product Details:

VELAKAST TABLETS
VELAKAST is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and velpatasvir is an NS5A inhibitor. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. The tablets include the following inactive ingredients: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: Titanium Dioxide IP and Brilliant Blue FCF, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Effect of the drug
Thanks to the powerful composition of the drug, Velakast APRAZER HEALTHCARE is widely used to fight the hepatitis C virus of genotypes 1-6. The drug may be given as a monotherapy or for combined treatment with or without cirrhosis. The high effectiveness of the drug against all genotypes of HCV is due to the presence in its composition:
Sofosbuvir: The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5(2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran- 2yl)methoxy  (phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3 O9 P and a molecular weight of 529.45. Sofosbuvir is a white to off-white crystalline solid with a solubility of at least 2 mg/mL across the pH range of 2–7.7 at 37°C and is slightly soluble in water.
Velpatasvir: The IUPAC name for velpatasvir is Methyl {(1R)-2-[(2S,4S)-2-(5-{2[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl) amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]1,11-dihydro[2]benzopyrano[4′,3′:6,7]naphtho[1,2-d]imidazol-9- yl}-1H-imidazol-2-yl)-4(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate. It has a molecular formula of C49H54 N8 O8 and a molecular weight of 883.0. Velpatasvir is practically insoluble (less than 0.1 mg/mL) above pH 5, slightly soluble (3.6 mg/mL) at pH 2, and soluble (greater than 36 mg/mL) at pH 1.2.
Mechanism of Action
VELAKAST is a fixed-dose combination of sofosbuvir and velpatasvir which are direct-acting antiviral agents against the hepatitis C virus Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a with an IC50 value ranging from 0.36 to 3.3 micromolar. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase. Velpatasvir is an inhibitor of the HCV NS5A protein, which is required for viral replication. Resistance selection in cell culture and cross-resistance studies indicates velpatasvir targets NS5A as its mode of action.
OVERDOSAGE
No specific antidote is available for overdose with VELAKAST. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with VELAKAST consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis can efficiently remove the predominant circulating metabolite of sofosbuvir, GS-331007, with an extraction ratio of 53%. Hemodialysis is unlikely to result in significant removal of velpatasvir since velpatasvir is highly bound to plasma protein.
HOW SUPPLIED AND STORAGE
Each bottle contains 28 tablets and is closed with a child-resistant closure. Storage: Store below 30°C

Additional Information:

• Delivery Time: 1 to 2 Days

Product Details:

Sofokast Tablet
Composition: Each film coated tablet Contains:Sofosbuvir 400 mgColours: Red Oxide of iron & Titanium Dioxide IP
The medicinal product "Sofosbuvir" is treated with chronic form of hepatitis C. Complex therapy with the use of this drug and other medications is prescribed for adult patients. The drug also treats patients with HIV and co-infections.The active component of the tablets is sophosbuvir. They are coated and contain 400 mg of the basic substance. The package contains 28 tablets.
Indications for use of the drug
The drug "Sofosbuvir" is prescribed for patients with hepatitis C, when the disease has passed into a chronic form. A combined approach is used for the effectiveness of treatment. It is possible to use medicament in cases when the patient has HIV in addition to hepatitis.
Contraindications to taking the drug "Sofosbuvir"
The drug is not used for hypersensitivity to substances that are present in its composition. Despite the fact that the drug does not affect fertility, it is rarely prescribed to women in their reproductive years. The use of the drug during pregnancy and breastfeeding is not recommended, as it can be harmful to the child. When pregnancy occurs, the combination of Sofosbuvira with such drugs as Interferon alfa and Ribavirin may have a negative effect on its course. For this reason, during the period of treatment, the child's bearing is undesirable. The experiments, during which the drug "Sofosbuvir" was tested in animals, showed that this drug has a slight negative impact on the offspring. Before you start taking it, you should carefully study the instructions for the drug and consult with a specialist.
Side Effect
Side effects are fully dependent on those drugs that are used in addition to Sofosbuvir, t. the main component can cause only headache and mild weakness. 
We describe the possible negative effects with different combinations of Sofosbuvira in the course of treatment at 12 weeks:
Ribavirin, more than 10% of cases . Blood can decrease the concentration of hemoglobin and increase the bilirubin index, insomnia, nausea may occur.
Ribavirin, up to 10% . Anemia, depression, dyspnea, cough, disorders in the digestive tract, hair loss, itching on the skin, cramps, pains in the joints and back and some others.
Interferon alfa and Ribavirin, more than 10% of cases . There is anemia, a decrease in the number of platelets and lymphocytes, impaired appetite, dizziness, insomnia, shortness of breath, diarrhea, vomiting, nausea, increased bilirubin, myalgia, joint pain, irritability, rashes and itching on the skin, fever,
Interferon alfa and ribavirin, less than 10% . Depression, anxiety, weight loss, migraine, impaired vision, memory and concentration, constipation, reflux, cramps, back and chest pain, asthenia, hair loss.
How Supplied / Storage and Handling
Sofokast tablets are available in bottle pack of 28 tablets along with one silicagel bag and closed  with child-resistant closure, housed in a carton along with leaflet.
Store between 15°C and 30°C 
Dispense only in original containerDo not use if seal over bottle opening is broken or missing

Additional Information:

• Delivery Time: 1 to 10 Days

Product Details:

Hepbest Tablet is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. It prevents the multiplication of viruses in human cells. This stops the virus from producing new viruses and clears up your infection

Product Details:

Daclatasvir 60mg Tablets are an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body. Daclatasvir is used to treat genotype 3 chronic hepatitis C in adults without cirrhosis. This medicine is given together with another drug called sofosbuvir. Daclatasvir may also be used for purposes not listed in this medication guide.

Features:

No side effects

Accurate composition

High purity